The development of well‐controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH‐controlled drug delivery system, utilizing reducing graphene oxide (rGO)‐polymer self‐assembly films as carriers, for the preparation of effective drug nanorods and nanoparticles. In this system, the rGO‐polymer carriers were constructed by the alternating assembly of poly‐l‐lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO‐polymer cores, which possess a positively charged surface as the desired template, could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions. The DOX embedding efficiency and the morphology of the drug nanocomposites could be controlled by the number of rGO‐polymer bilayers and concentration of the rGO‐polymer bilayers and the initial DOX concentration. Importantly, the release of DOX could be regulated by controlling the pH and by using a NIR laser. Under acidic conditions, the interactions between the PASP layer and DOX molecules can be broken, resulting in gradual release of the DOX molecules. Upon NIR irradiation, the release of DOX could be further accelerated and a photothermal effect from rGO induced. Cellular uptake and cytotoxicity experiments indicate that the drug nanocomposites possess effective anticancer activity. Thus, in this work, we present a useful strategy for the fabrication of pH‐responsive drug nanocomposites for combined photothermal and chemical therapy. The nanocomposite can be used as a potential drug delivery system for practical cancer treatment.

中文翻译：

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具有pH开关的rGO /（PLL / PASP）3 @ DOX纳米棒的制备，用于光热疗法和化学疗法

开发稳定且高效的抗癌药物递送控制良好的药物载体具有挑战性。本文中，我们报告了一种新型的pH控制药物递送系统，该系统利用氧化石墨烯（rGO）聚合物自组装薄膜作为载体，来制备有效的药物纳米棒和纳米颗粒。在该系统中，RGO聚合物载体是由交替构成聚-组件升rGO表周围的赖氨酸（PLL）和聚天冬氨酸（PASP）。此外，rGO聚合物核具有带正电的表面作为所需模板，可以通过静电相互作用与带负电的阿霉素（DOX）组装在一起。药物纳米复合材料的DOX包埋效率和形态可以通过rGO聚合物双层的数量，rGO聚合物双层的浓度和初始DOX浓度来控制。重要的是，可以通过控制pH值和使用NIR激光来调节DOX的释放。在酸性条件下，PASP层与DOX分子之间的相互作用会被破坏，导致DOX分子逐渐释放。在NIR照射下，DOX的释放可以进一步加速，并且可以诱导rGO产生光热效应。细胞摄取和细胞毒性实验表明该药物纳米复合物具有有效的抗癌活性。因此，在这项工作中，我们提出了一种用于组合光热和化学疗法的pH响应药物纳米复合材料的有用策略。纳米复合材料可用作潜在的药物输送系统，用于实际的癌症治疗。