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Lithium Chloride Catalyzed Asymmetric Domino Aza‐Michael Addition/[3 + 2] Cycloaddition Reactions for the Synthesis of Spiro‐ and Bicyclic α,β,γ‐Triamino Acid Derivatives
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-17 , DOI: 10.1002/ejoc.201800585 David Just 1 , Daniel Hernandez-Guerra 1 , Susanne Kritsch 2 , Radek Pohl 1 , Ivana Císařová 3 , Peter G. Jones 2 , Richard Mackman 4 , Gina Bahador 4 , Ullrich Jahn 1
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-17 , DOI: 10.1002/ejoc.201800585 David Just 1 , Daniel Hernandez-Guerra 1 , Susanne Kritsch 2 , Radek Pohl 1 , Ivana Císařová 3 , Peter G. Jones 2 , Richard Mackman 4 , Gina Bahador 4 , Ullrich Jahn 1
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Angularly and peri‐fused tricyclic pyrrolidinopyrazolines are efficiently prepared by LiCl catalyzed domino aza‐Michael addition‐1,3‐dipolar cycloaddition. The resulting tricyclic pyrrolidinopyrazolines can be easily transformed to spirocyclic or condensed bicyclic α,β,γ‐triamino acid derivatives.
中文翻译：
氯化锂催化不对称多米诺骨牌Aza-Michael加成/ [3 + 2]环加成反应合成螺环和双环α，β，γ-三氨基酸衍生物
通过LiCl催化的多米诺骨牌aza-Michael加成-1,3-偶极环加成可有效地制备角和周边稠合的三环吡咯并吡唑啉。生成的三环吡咯并吡唑啉可以轻松转化为螺环或稠合的双环α，β，γ-三氨基酸衍生物。
更新日期：2018-08-17
中文翻译：
氯化锂催化不对称多米诺骨牌Aza-Michael加成/ [3 + 2]环加成反应合成螺环和双环α，β，γ-三氨基酸衍生物
通过LiCl催化的多米诺骨牌aza-Michael加成-1,3-偶极环加成可有效地制备角和周边稠合的三环吡咯并吡唑啉。生成的三环吡咯并吡唑啉可以轻松转化为螺环或稠合的双环α，β，γ-三氨基酸衍生物。
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