AKT (v-Akt oncogene), a Ser/Thr protein kinase, was also identified as protein kinase B (PKB) (reviewed in ref. 1). There are three known isoforms of AKT1-3. All these AKT isoforms are highly conserved and are recruited to the plasma membrane where they bind to PIP_3,4,5 via the PH-domain and are phosphorylated. While Lučić et al. (2) studied AKT1, the study is applicable to all of the AKT isoforms. Among the three AKT isoforms, AKT2 is extensively studied due to its critical role in insulin signaling (3). AKT is a central hub for cellular signal transduction, relaying information …

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在最近发现之后如何解释下游靶标的AKT磷酸化[生物科学]

AKT（v-Akt癌基因），一种Ser / Thr蛋白激酶，也被鉴定为蛋白激酶B（PKB）（参见参考文献1）。AKT1-3有三种已知的同工型。所有这些AKT亚型都高度保守，被募集到质膜上，在那里它们通过PH结构域与PIP _3、4、5结合并被磷酸化。而卢奇奇等人。（2）研究了AKT1，该研究适用于所有的AKT同工型。在这三种AKT亚型中，由于AKT2在胰岛素信号传导中的关键作用，人们对其进行了广泛的研究（3）。AKT是用于蜂窝信号传导，中继信息的中央枢纽……