pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide 131I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer†,Journal of Materials Chemistry B

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pH-Sensitive nanogels based on the electrostatic self-assembly of radionuclide 131I labeled albumin and carboxymethyl cellulose for synergistic combined chemo-radioisotope therapy of cancer†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-15 00:00:00 , DOI: 10.1039/c8tb01295d
Kefeng Liu _{1,

2,

3,

4} , Dan Zheng _{1,

2,

3,

4} , Jingyang Zhao _{1,

2,

3,

4} , Yinghua Tao _{1,

2,

3,

4} , Yingsa Wang _{1,

2,

3,

4} , Jing He _{1,

2,

3,

4} , Jiandu Lei _{1,

2,

3,

4} , Xingjun Xi _{5,

6,

7,

8}

Affiliation

Development of biocompatible and biodegradable nanocarriers with multiple functionalities has attracted great interest in recent years. In this study, a hybrid hydrogel nanoparticle (nanogel) platform based on the self-assembly of carboxymethyl cellulose (CMC) and bovine serum albumin (BSA) is presented for the first time. It was facile to realize the efficient co-delivery of radionuclide ¹³¹I and chemotherapeutic drugs such as camptothecin (CPT) to achieve the combined chemo-radioisotope therapy of cancer. Notably, a nanogel was prepared by a simple and green electrostatic interaction approach, instead of chemical reaction, showing typical spherical shape with average size about 120 nm, high drug loading capacity, robust stability and low hemolysis. Interestingly, such nanogels exhibited pH-dependent drug release profile, leading to significant reduction of damage to normal tissues. Furthermore, the as-prepared nanogels could effectively promote intracellular uptake, prolong blood circulation time and enhance accumulation in the tumor tissues. As a result, an excellent therapeutic effect was achieved both in vitro and in vivo through combined chemo-radioisotope therapy. Collectively, this study presents the preparation of a novel green nanocarrier by a reliable and simple approach, and offers an effective strategy for the combination of chemotherapy and radiotherapy.

中文翻译：

基于放射性核素¹³¹ I标记的白蛋白和羧甲基纤维素的静电自组装的pH敏感纳米凝胶，用于癌症的化学放射联合协同联合治疗†

近年来，具有多种功能的生物相容性和可生物降解的纳米载体的开发引起了人们的极大兴趣。在这项研究中，首次提出了基于羧甲基纤维素（CMC）和牛血清白蛋白（BSA）自组装的杂化水凝胶纳米颗粒（nanogel）平台。轻松实现放射性核素¹³¹的高效共输送I和喜树碱（CPT）等化学治疗药物可实现癌症的化学-放射性同位素联合治疗。值得注意的是，通过简单且绿色的静电相互作用方法而不是化学反应制备了纳米凝胶，其显示出平均尺寸为约120nm的典型球形，高载药量，稳健稳定性和低溶血性。有趣的是，这样的纳米凝胶表现出pH依赖性的药物释放曲线，从而导致对正常组织损伤的显着降低。此外，所制备的纳米凝胶可以有效地促进细胞内摄取，延长血液循环时间并增强在肿瘤组织中的积累。结果，在体外和体内均获得了优异的治疗效果。通过化学-放射性同位素联合疗法。总体而言，这项研究提出了一种可靠且简单的方法来制备新型绿色纳米载体，并为化学疗法和放射疗法的结合提供了有效的策略。

更新日期：2018-06-15

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