Abstract The materials of the dental barrier membranes (DBM), which is widely used for effective alveolar bone reconstruction, require high biocompatibility and additional functions. In this study, we prepared a chitosan/polyurethane (CSP) nanofibrous membrane incorporated silver nanoparticles (AgNPs) within the membrane. Characterization of CS-AgNP/polyurethane composite (AgCSP) nanofiber membranes showed that AgNPs were well embedded in chitosan membranes. In addition, biocompatibility and antibacterial effect against Porphyromonas gingivalis of the AgCSP was demonstrated by viability analysis and growth inhibition test. Collectively, AgCSP nanofiber membrane with antibacterial activity as well as biocompatibility may be useful in DBM and other tissue engineering applications.

中文翻译：

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用于牙科屏障膜应用的含银纳米粒子的抗菌壳聚糖膜的制备

摘要 牙屏障膜（DBM）材料广泛用于有效的牙槽骨重建，需要高生物相容性和附加功能。在这项研究中，我们制备了一种壳聚糖/聚氨酯 (CSP) 纳米纤维膜，在膜内加入了银纳米粒子 (AgNPs)。CS-AgNP/聚氨酯复合材料 (AgCSP) 纳米纤维膜的表征表明，AgNPs 很好地嵌入壳聚糖膜中。此外，通过活力分析和生长抑制试验证明了 AgCSP 对牙龈卟啉单胞菌的生物相容性和抗菌作用。总之，具有抗菌活性和生物相容性的 AgCSP 纳米纤维膜可用于 DBM 和其他组织工程应用。