Trifluoromethyl‐containing compounds play a significant role in medicinal chemistry, materials and fine chemistry. Although direct C−H trifluoromethylation has been achieved on Csp²−H bonds, direct conversion of Csp³−H bonds to Csp³−CF₃ remains challenging. We report herein an efficient protocol for the selective trifluoromethylation of benzylic C−H bonds. This process is mediated by a combination Cu^III−CF₃ species and persulfate salts. A wide range of methylarenes can be selectively trifluoromethylated at the benzylic positions. A combination of experimental and theoretical mechanistic studies suggests that the reaction involves a radical intermediate and a Cu^III−CF₃ species as the CF₃ transfer reagent.

中文翻译：

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铜介导的苄基Csp3-H键的三氟甲基化。

含三氟甲基的化合物在药物化学，材料和精细化学中起着重要作用。尽管已经在Csp ² -H键上实现了直接的CH三氟甲基化，但是将Csp ³ -H键直接转换为Csp ³ -CF ₃仍然具有挑战性。我们在这里报告了苄基CH键的选择性三氟甲基化的有效方案。该过程由Cu ^III -CF ₃物种和过硫酸盐的组合介导。各种各样的甲基​​芳烃可以在苄基位置被选择性地三氟甲基化。实验和理论机理研究的组合表明，该反应涉及自由基中间体和Cu ^III-CF ₃种类作为CF ₃转移试剂。