Microgel core/shell architectures as targeted agents for fibrinolysis†,Biomaterials Science

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Microgel core/shell architectures as targeted agents for fibrinolysis†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-06-14 00:00:00 , DOI: 10.1039/c8bm00119g
Purva Kodlekere _{1,

2,

3,

4} , L. Andrew Lyon _{1,

2,

3,

4,

5}

Affiliation

We demonstrate the utility of microgel core/shell structures conjugated to fibrin-specific peptides as fibrinolytic agents. Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots. These results suggest the potential utility of peptide–microgel hybrids in clot disruption and clotting modulation.

中文翻译：

Microgel核/壳结构可作为纤维蛋白溶解的靶向药物†

我们证明了偶联到血纤蛋白特异性肽上的微凝胶核/壳结构作为血纤蛋白溶解剂的实用性。仅通过利用血块的动态性质，观察到与肽GPRPFPAC（GPRP）缀合的基于聚（N-异丙基甲基丙烯酰胺）（pNIPMAm）的微凝胶引起纤维蛋白血块腐蚀。这些结果表明，肽-微凝胶杂交体在凝块破坏和凝块调节中具有潜在的实用性。

更新日期：2018-06-14

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