Cobalt(I)‐Catalyzed Cycloaddition of Functionally Substituted Alkynes and 1,3‐Diynes to 1,3,5,7‐Cyclooctatetraene in the Synthesis of Bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes,ChemistrySelect

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Cobalt(I)‐Catalyzed Cycloaddition of Functionally Substituted Alkynes and 1,3‐Diynes to 1,3,5,7‐Cyclooctatetraene in the Synthesis of Bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes
ChemistrySelect ( IF 1.9 ) Pub Date : 2018-06-13 , DOI: 10.1002/slct.201801028
Vladimir A. D'yakonov ₁ , Gulnara N. Kadikova ₁ , Guzel F. Gazizullina ₁ , Usein M. Dzhemilev ₁

Affiliation

The [6π+2π]‐cycloaddition of O‐, S‐, N‐, Hal‐, and Si‐containing alkynes and 1,3‐diynes to 1,3,5,7‐cyclooctatetraene was accomplished for the first time using a Co(acac)₂‐based four‐component catalytic system [Co(acac)₂/dppe/Zn/ZnI₂] to give previously undescribed functionally substituted bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes in 72–95% yields. These products are of interest as key monomers for the synthesis of natural and synthetic biologically active compounds.

中文翻译：

钴（I）催化双取代[4.2.2] deca-2、4、7、9-四烯合成中功能取代的炔烃和1,3-二炔至1,3,5,7-环辛酸酯的环加成反应

含O，S，N，Hal和Si的炔烃和1,3-二炔的[6π+2π]-环加成反应是第一次使用基于Co（acac）₂的四组分催化体系[Co（acac）₂ / dppe / Zn / ZnI ₂ ]，得到以前未描述的功能取代的双环[4.2.2] deca-2,4,7,9-四烯72–95％的产量。这些产品作为合成天然和合成生物活性化合物的关键单体而受到关注。

更新日期：2018-06-13

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