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Phosphorylated peptides from Antarctic krill (Euphausia superba) ameliorated osteoporosis by activation of osteogenesis-related MAPKs and PI3K/AKT/GSK-3β pathways in dexamethasone-treated mice
Journal of Functional Foods ( IF 3.8 ) Pub Date : 2018-06-13 , DOI: 10.1016/j.jff.2018.06.004
Lihua Han , Xiangzhao Mao , Kai Wang , Yuanyuan Li , Meihui Zhao , Jingfeng Wang , Changhu Xue

In this study, the effects of phosphorylated peptides from Antarctic krill (PP-AKP) on osteoporosis induced by dexamethasone were investigated in vivo. Results showed that PP-AKP significantly improved bone turnover status, reduced bone loss and degeneration of microarchitecture, in addition to accelerated bone formation. Further mechanism investigation revealed that PP-AKP suppressed the mRNA expression of MKP-1 and CB1, which activated the downstream osteogenesis-related MAPKs and PI3K/AKT/GSK-3β signaling pathways through elevation of the expression of the key factors p38, ERK, PI3K, AKT and β-catenin, in addition to osteogenic nuclear transcription factors Runx2 and OSX. Additionally, reduction in number of adipocytes and an increase in trabeculae in the bone marrow cavity, in addition to a decrease in abdominal adipose further verified that PP-AKP augmented bone formation with a comparable reduction in the accumulation of fat. In conclusion, PP-AKP ameliorated osteoporosis via promoting MAPKs and PI3K/AKT/GSK-3β pathways related to bone formation in dexamethasone-treated mice.



中文翻译:

南极磷虾(Euphausia superba)的磷酸化肽通过激活地塞米松治疗的小鼠中成骨相关的MAPK和PI3K / AKT /GSK-3β途径改善了骨质疏松

在这项研究中,在体内研究南极磷虾(PP-AKP)磷酸化肽对地塞米松诱导的骨质疏松的影响。结果表明,PP-AKP可以显着改善骨骼更新状态,减少骨骼流失和微结构退化,此外还可以加速骨骼形成。进一步的机制研究表明,PP-AKP抑制了MKP-1和CB1的mRNA表达,从而通过提高关键因子p38,ERK, PI3K,AKT和β-连环蛋白,以及成骨核转录因子Runx2和OSX。此外,除腹部脂肪减少之外,骨髓腔中脂肪细胞数量的减少和小梁的增加进一步证实了PP-AKP可以增加骨骼的形成,并具有类似的脂肪积聚减少。综上所述,

更新日期:2018-06-13
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