Therapy by targeting cancer stem cells (CSCs) is an eligible method to eradicate malignant human tumors. A synthetic triepoxide derivative, teroxirone, was reported effective against the growth of human lung cancer cells by injuring cellular mitochondria functions. And yet it remains unclear if the residual but malicious CSCs can be effectively dissipated following treatment. The current study further affirmed that teroxirone inhibited the propagation of CSCs as enriched from NSCLC cells by inducing p53 that lead to ultimate apoptosis. More evidence supported that the reduced stemness of the spheroids was associated with apoptotic death. The results consolidate the notion that teroxirone is a viable and effective therapeutic agent for eradicating human lung cancer.

通过靶向癌症干细胞（CSC）进行治疗是根除恶性人类肿瘤的合格方法。据报道，合成的三环氧化物衍生物teroxirone可通过损伤细胞线粒体功能有效对抗人肺癌细胞的生长。然而，尚不清楚是否可以在治疗后有效消散残留的但恶意的CSC。当前的研究进一步证实了特罗西酮通过诱导导致最终细胞凋亡的p53抑制了从NSCLC细胞中富集的CSC的繁殖。越来越多的证据表明，球状茎的减少与凋亡的死亡有关。该结果巩固了teroxirone是一种可根除人类肺癌的可行且有效的治疗剂的观念。