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Lipid-Protein Interactions Are Unique Fingerprints for Membrane Proteins.
ACS Central Science ( IF 12.7 ) Pub Date : 2018-06-13 , DOI: 10.1021/acscentsci.8b00143 Valentina Corradi 1 , Eduardo Mendez-Villuendas 1 , Helgi I Ingólfsson 2 , Ruo-Xu Gu 1 , Iwona Siuda 1 , Manuel N Melo 2 , Anastassiia Moussatova 1 , Lucien J DeGagné 1 , Besian I Sejdiu 1 , Gurpreet Singh 1 , Tsjerk A Wassenaar 2 , Karelia Delgado Magnero 1 , Siewert J Marrink 2 , D Peter Tieleman 1
ACS Central Science ( IF 12.7 ) Pub Date : 2018-06-13 , DOI: 10.1021/acscentsci.8b00143 Valentina Corradi 1 , Eduardo Mendez-Villuendas 1 , Helgi I Ingólfsson 2 , Ruo-Xu Gu 1 , Iwona Siuda 1 , Manuel N Melo 2 , Anastassiia Moussatova 1 , Lucien J DeGagné 1 , Besian I Sejdiu 1 , Gurpreet Singh 1 , Tsjerk A Wassenaar 2 , Karelia Delgado Magnero 1 , Siewert J Marrink 2 , D Peter Tieleman 1
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Cell membranes contain hundreds of different proteins and lipids in an asymmetric arrangement. Our current understanding of the detailed organization of cell membranes remains rather elusive, because of the challenge to study fluctuating nanoscale assemblies of lipids and proteins with the required spatiotemporal resolution. Here, we use molecular dynamics simulations to characterize the lipid environment of 10 different membrane proteins. To provide a realistic lipid environment, the proteins are embedded in a model plasma membrane, where more than 60 lipid species are represented, asymmetrically distributed between the leaflets. The simulations detail how each protein modulates its local lipid environment in a unique way, through enrichment or depletion of specific lipid components, resulting in thickness and curvature gradients. Our results provide a molecular glimpse of the complexity of lipid-protein interactions, with potentially far-reaching implications for our understanding of the overall organization of real cell membranes.
中文翻译：
脂蛋白相互作用是膜蛋白的独特指纹。
细胞膜以不对称排列包含数百种不同的蛋白质和脂质。由于对研究具有所需时空分辨率的脂类和蛋白质波动的纳米级组装的挑战，我们目前对细胞膜的详细组织的了解仍然很难捉摸。在这里，我们使用分子动力学模拟来表征10种不同膜蛋白的脂质环境。为了提供逼真的脂质环境，蛋白质被嵌入模型质膜中，其中代表了60多种脂质，这些脂质不对称地分布在小叶之间。模拟详细说明了每种蛋白质如何通过富集或耗尽特定脂质成分，以独特的方式调节其局部脂质环境，从而产生厚度和曲率梯度。
更新日期：2018-06-13
中文翻译：
脂蛋白相互作用是膜蛋白的独特指纹。
细胞膜以不对称排列包含数百种不同的蛋白质和脂质。由于对研究具有所需时空分辨率的脂类和蛋白质波动的纳米级组装的挑战，我们目前对细胞膜的详细组织的了解仍然很难捉摸。在这里，我们使用分子动力学模拟来表征10种不同膜蛋白的脂质环境。为了提供逼真的脂质环境，蛋白质被嵌入模型质膜中，其中代表了60多种脂质，这些脂质不对称地分布在小叶之间。模拟详细说明了每种蛋白质如何通过富集或耗尽特定脂质成分，以独特的方式调节其局部脂质环境，从而产生厚度和曲率梯度。
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