A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for the detection of two biomarkers†,Journal of Materials Chemistry B

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A single-interface photoelectrochemical sensor based on branched TiO2 nanorods@strontium titanate for the detection of two biomarkers†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-14 00:00:00 , DOI: 10.1039/c8tb00992a
Jie Xue _{1,

2,

3,

4} , Chaomin Gao _{1,

2,

3,

4} , Lina Zhang _{2,

3,

4,

5} , Kang Cui _{1,

2,

3,

4} , Wenxing He _{2,

3,

4,

6} , Jinghua Yu _{1,

2,

3,

4}

Affiliation

In this study, a single-interface photoelectrochemical (PEC) sensor for detecting two antigens, alpha fetoprotein (AFP) and cancer antigen 153 (CA 153), was achieved based on the heterostructure of branched titanium dioxide nanorods (B-TiO₂ NRs)@strontium titanate (SrTiO₃) heterostructures. The B-TiO₂ NRs@SrTiO₃ heterostructure, prepared by a facile hydrothermal method with the feature of enhanced photogenerated charge carrier separation properties, was first employed as a photoactive substrate for anchored analyst. In order to achieve the goal of successfully detecting two biomarkers at a single interface, the two specific enzyme tags β-galactosidase and acetylcholine esterase linked with a secondary detection antibody were utilized to catalytically hydrolyze p-aminophenyl galactopyranoside and acetylthiocholine to p-aminophenol and thiocholine, respectively. Based on the above enzyme-catalyzed reactions to produce sacrificial electron donors, the photocurrent signals generated from different analytes could be distinguished at a single interface. The results demonstrate that this single-interface PEC sensor not only provides a method for the early detection of AFP and CA 153 but also provides new insight into designing a novel PEC sensor for the detection of two biomarkers with high efficiency and a simple method of operation.

中文翻译：

基于支化的TiO ₂纳米棒@钛酸锶的单界面光电化学传感器，用于检测两种生物标记物†

在这项研究中，基于支化二氧化钛纳米棒（B-TiO ₂ NRs）的异质结构，实现了一种用于检测两种抗原α甲胎蛋白（AFP）和癌症抗原153（CA 153）的单界面光电化学（PEC）传感器。钛酸锶（SrTiO ₃）异质结构。B-TiO ₂ NRs @ SrTiO ₃通过简便的水热法制备的具有增强的光生电荷载流子分离特性的异质结构首先被用作锚定分析物的光敏底物。为了达到在单个界面上成功检测两个生物标志物的目的，利用与第二种检测抗体连接的两个特异性酶标签β-半乳糖苷酶和乙酰胆碱酯酶将对氨基苯吡喃半乳糖苷和乙酰硫胆碱催化水解为p-氨基苯酚和硫胆碱。基于上述酶催化反应产生的牺牲电子供体，可以在单个界面上区分由不同分析物产生的光电流信号。结果表明，这种单界面PEC传感器不仅为早期检测AFP和CA 153提供了一种方法，而且还为设计新型高效检测两种生物标志物的PEC传感器和一种简单的操作方法提供了新的见解。。

更新日期：2018-06-14

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