Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines,Green Chemistry

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Anodic benzylic C(sp3)–H amination: unified access to pyrrolidines and piperidines
Green Chemistry ( IF 9.3 ) Pub Date : 2018-06-13 , DOI: 10.1039/c8gc01411f
Sebastian Herold _{1,

2,

3,

4} , Daniel Bafaluy _{1,

2,

3,

4} , Kilian Muñiz _{1,

2,

3,

4,

5}

Affiliation

An electrochemical aliphatic C–H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C–H amination strategy involves anodic C–H activation to generate a benzylic cation, which is efficiently trapped by a nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6-membered ring formations.

中文翻译：

阳极苄基C（sp ³）–H胺化：统一获得吡咯烷和哌啶

开发了一种电化学脂肪族CH胺化策略，以在统一的反应方案中访问吡咯烷和哌啶的重要杂环基序。这种前所未有的C–H胺化策略的机制涉及阳极C–H活化以生成苄基阳离子，该阳离子被氮亲核试剂有效捕获。对于包含5元和6元环形成的40个实例证明了该方法的适用性。

更新日期：2018-07-16

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