In the present work composite membranes were produced by combining magnetic nanoparticles (NPs) with cellulose acetate (CA) membranes for magnetic hyperthermia applications. The non-woven CA membranes were produced by electrospinning technique, and magnetic NPs were incorporated by adsorption at fibers surface or by addition to the electrospinning solution. Therefore, different designs of composite membranes were obtained. Superparamagnetic NPs synthesized by chemical precipitation were stabilized either with oleic acid (OA) or dimercaptosuccinic acid (DMSA) to obtain stable suspensions at physiological pH. The incorporation of magnetic NP into CA matrix was confirmed by scanning and transmission electron microscopy. The results showed that adsorption of magnetic NPs at fibers’ surface originates composite membranes with higher heating ability than those produced by incorporation of magnetic NPs inside the fibers. However, adsorption of magnetic NPs at fibers’ surface can cause cytotoxicity depending on the NPs concentration. Tensile tests demonstrated a reinforcement effect caused by the incorporation of magnetic NPs in the non-woven membrane.

在本工作中，通过将磁性纳米颗粒（NPs）与醋酸纤维素（CA）膜结合起来生产复合膜，以用于磁热疗。非织造CA膜是通过静电纺丝技术生产的，磁性NP通过在纤维表面的吸附或通过添加到静电纺丝溶液中而掺入。因此，获得了不同设计的复合膜。通过化学沉淀法合成的超顺磁性NPs可通过油酸（OA）或二巯基琥珀酸（DMSA）稳定化，从而在生理pH值下获得稳定的悬浮液。通过扫描和透射电子显微镜确认了磁性NP掺入CA基质中。结果表明，与在纤维内部掺入磁性NP产生的复合膜相比，磁性NP在纤维表面的吸附产生的复合膜具有更高的加热能力。但是，磁性NP在纤维表面的吸附会导致细胞毒性，具体取决于NP的浓度。拉伸试验证明了由于在非织造膜中掺入磁性NP而引起的增强作用。