Abstract This article focuses on the design and implementation of model-based control strategies for real time control of crystal size distribution (CSD) in semi batch crystallization processes. The objective of the feedback controller is to reach a desired particle mean size while the standard deviation is controlled in a feedforward fashion. Alternative model-based control strategies are formulated and implemented for a target mean size. An image processing technique based on wavelet-fractal and energy signature analysis is employed to determine online CSD status for the controller’s corrective actions. To validate the proposed model-based control strategies, unseeded crystallization of sodium chloride in water using ethanol as antisolvent is performed in an experimental bench-scale semi-batch crystallizer.

中文翻译：

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在联合冷却-抗溶剂结晶过程中控制粒度分布的基于模型的方法

摘要 本文重点介绍半间歇结晶过程中用于实时控制晶体尺寸分布 (CSD) 的基于模型的控制策略的设计和实现。反馈控制器的目标是达到所需的颗粒平均尺寸，同时以前馈方式控制标准偏差。针对目标平均尺寸制定和实施替代的基于模型的控制策略。采用基于小波分形和能量特征分析的图像处理技术来确定控制器纠正动作的在线 CSD 状态。为了验证所提出的基于模型的控制策略，在实验台规模的半间歇结晶器中使用乙醇作为抗溶剂在水中进行氯化钠的非晶种结晶。