Quinoline–Glycomimetic Conjugates Reducing Lipogenesis and Lipid Accumulation in Hepatocytes,ChemBioChem

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Quinoline–Glycomimetic Conjugates Reducing Lipogenesis and Lipid Accumulation in Hepatocytes
ChemBioChem ( IF 2.6 ) Pub Date : 2018-07-13 , DOI: 10.1002/cbic.201800271
Subhadeep Palit ₁ , Sanghamitra Mukherjee ₁ , Sougata Niyogi ₂ , Anindyajit Banerjee ₃ , Dipendu Patra ₁ , Amit Chakraborty ₁ , Saikat Chakrabarti ₃ , Partha Chakrabarti ₂ , Sanjay Dutta ₁

Affiliation

Fat busters: Nonalcoholic fatty liver disease, which is characterized by excess accumulation of triglyceride in hepatocytes, is the major cause of chronic liver disease worldwide and no approved drug is available. Therefore, small molecules that decrease lipogenesis and lipid accumulation in hepatocytes by inhibiting the mechanistic target of rapamycin (mTOR) pathway have been developed.