Continuous‐Flow retro‐Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds,European Journal of Organic Chemistry

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Continuous‐Flow retro‐Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-13 , DOI: 10.1002/ejoc.201800682
Imane Nekkaa ₁ , Márta Palkó ₁ , István M. Mándity _{1,

2,

3} , Ferenc Miklós ₁ , Ferenc Fülöp _{1,

4}

Affiliation

An approach based on a highly controlled continuous‐flow (CF) retro‐Diels–Alder reaction was developed for the synthesis of new compounds. Using this approach, we were able to rapidly screen reaction conditions to obtain the desired pyrimidinone moieties in short reaction times and high yields. We also present an alternative route for the synthesis of intermediates by CF cyclization.