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Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense†
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2018-06-13 00:00:00 , DOI: 10.1039/c8qo00469b
Jin-Xin Zhao 1, 2, 3, 4, 5 , Cui-Ping Liu 1, 2, 3, 4, 5 , Meng-Meng Zhang 1, 2, 3, 4, 5 , Jia Li 1, 2, 3, 4, 5 , Jian-Min Yue 1, 2, 3, 4, 5
Affiliation  

Dysohonin A (1), a meroditerpenoid incorporating an unprecedented 6,15,6-fused heterotricyclic ring system, along with three new biogenetically related meroditerpenoids dysohonins B–D (2–4) were isolated from Dysoxylum hongkongense. Their structures with absolute configurations were well established by a combined method. The plausible biosynthetic pathways of 1–4 were proposed. All the compounds exhibited PTP1B inhibitory activities.

中文翻译:

Dysohonin A,一种融合了6,15,6-稠合杂环系统的二萜类化合物,来自Dysoxylum hongkongense

Dysohonin A(1)是一种掺入了前所未有的6,15,6-稠合杂环三环的类双萜,并从Dysoxylum hongkongense中分离出了三种新的与生物遗传相关的类二萜类植物dysohonins B–D(2-4)。通过组合方法可以很好地确定它们具有绝对构型的结构。提出了可能的1-4生物合成途径。所有化合物均表现出PTP1B抑制活性。
更新日期:2018-06-13
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