Phyllostictine A: total synthesis, structural verification and determination of substructure responsible for plant growth inhibition†,Chemical Communications

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Phyllostictine A: total synthesis, structural verification and determination of substructure responsible for plant growth inhibition†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-13 00:00:00 , DOI: 10.1039/c8cc03349h
Martin Riemer ₁ , Veselina V Uzunova , Nastja Riemer , Guy J Clarkson , Nicole Pereira , Richard Napier , Michael Shipman

Affiliation

The first total synthesis of phyllostictine A (PA) is reported, which confirms the structure of this fungal metabolite and its (6S,7R,8S)-stereochemistry. Both synthetic PA and an analogue containing the 5-methylene-1,5-dihydro-2H-pyrrol-2-one nucleus exhibit μM inhibitory activity in root growth assays against Arabidopsis thaliana, indicating that this heterocyclic subunit is key to the herbicidal activity of the natural product.

中文翻译：

Phyllostictine A：植物生长抑制亚结构的全合成、结构验证和测定†

首次报道了叶霉碱 A (PA) 的全合成，证实了这种真菌代谢物的结构及其 (6 S ,7 R ,8 S )-立体化学。合成的 PA 和含有 5-methylene-1,5-dihydro-2 H -pyrrol-2-one 核的类似物在针对拟南芥的根生长试验中均表现出 μM 抑制活性，表明该杂环亚基是除草活性的关键的天然产物。

更新日期：2018-06-13

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