C–H oxygenation at tertiary carbon centers using iodine oxidant†,Chemical Communications

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C–H oxygenation at tertiary carbon centers using iodine oxidant†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-13 00:00:00 , DOI: 10.1039/c8cc03735c
Kensuke Kiyokawa _{1,

2,

3,

4,

5} , Ryo Ito _{1,

2,

3,

4,

5} , Kenta Takemoto _{1,

2,

3,

4,

5} , Satoshi Minakata _{1,

2,

3,

4,

5}

Affiliation

An oxidation system in which iodic acid (HIO₃) is used as an oxidant in the presence of N-hydroxyphthalimide (NHPI) permitted the selective hydroxylation of tertiary C–H bonds and the lactonization of carboxylic acids containing a tertiary carbon center. These reactions are operationally simple and proceed under metal-free conditions using commercially available reagents, thus offering an ideal tool for the efficient oxidation of C–H bonds at tertiary carbon centers.

中文翻译：

使用碘氧化剂在三级碳中心进行C–H氧化†

在N-羟基邻苯二甲酰亚胺（NHPI）存在的情况下，使用碘酸（HIO ₃）作为氧化剂的氧化系统允许叔C–H键的选择性羟基化和含叔碳中心的羧酸的内酯化。这些反应操作简单，可使用市售试剂在无金属条件下进行，因此为在叔碳中心高效氧化C–H键提供了理想的工具。

更新日期：2018-06-13

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