Exposure of Lung Epithelial Cells to Photochemically Aged Secondary Organic Aerosol Shows Increased Toxic Effects,Environmental Science & Technology Letters

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Exposure of Lung Epithelial Cells to Photochemically Aged Secondary Organic Aerosol Shows Increased Toxic Effects
Environmental Science & Technology Letters ( IF 8.9 ) Pub Date : 2018-06-13 , DOI: 10.1021/acs.estlett.8b00256
Pratiti Home Chowdhury ₁ , Quanfu He ₁ , Tatyana Lasitza Male ₁ , William H. Brune ₂ , Yinon Rudich ₁ , Michal Pardo ₁

Affiliation

Adverse health effects due to exposure to particulate matter (PM) are among the most important global environmental health risks. However, the effects of exposure to secondary organic aerosols (SOA), a major component of the global aerosol, are largely unknown. Here we exposed lung epithelial cells (A549) to fresh and aged SOA particles and investigated the effect of SOA atmospheric aging on cell viability and gene expression. Naphthalene- and α-pinene-derived SOA were formed in an oxidation flow reactor that simulates atmospheric SOA formation and aging dominated by OH radical oxidation under NO_x-free conditions. The SOA mass and chemical composition were characterized on-line using a scanning mobility particle sizer and aerosol mass spectrometer. Fresh and aged SOA were directed to an air–liquid interface cell exposure system. Aged naphthalene- and α-pinene-derived SOA were somewhat more toxic than fresh SOA. Aged naphthalene SOA contained peroxide levels that were higher than those of fresh SOA. The level of induction of Nrf2 signaling increased following exposure to aged naphthalene SOA. Given the global prevalence of SOA and its observed toxicity, this study calls for more studies aimed at understanding the underlying mechanics.

中文翻译：

肺上皮细胞暴露于光化学老化的次要有机气溶胶显示增加的毒性作用

暴露于颗粒物（PM）对健康造成的不利影响是最重要的全球环境健康风险之一。然而，很大程度上不知道暴露于次级有机气溶胶（SOA）（全球气溶胶的主要成分）的影响。在这里，我们将肺上皮细胞（A549）暴露在新鲜和老化的SOA颗粒中，并研究了SOA大气老化对细胞活力和基因表达的影响。萘和α蒎烯衍生的SOA形成在模拟大气SOA形成和下NO被OH基团氧化老化为主的氧化流动反应器_X无条件。使用扫描迁移率粒度仪和气溶胶质谱仪对SOA的质量和化学成分进行在线表征。新鲜的和老化的SOA被引导至气液界面细胞暴露系统。老化的萘和α-pine烯来源的SOA的毒性要比新鲜的SOA更高。老化的萘SOA所含的过氧化物含量高于新鲜的SOA。暴露于老化的萘SOA后，Nrf2信号的诱导水平增加。考虑到SOA的全球流行性及其所观察到的毒性，本研究呼吁开展更多旨在了解底层机理的研究。

更新日期：2018-06-13

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