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Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles
ACS Nano ( IF 15.8 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1021/acsnano.7b06870 Na Li 1 , Qiaoqiao Sun 1 , Zhengze Yu 1 , Xiaonan Gao 1 , Wei Pan 1 , Xiuyan Wan 1 , Bo Tang 1
ACS Nano ( IF 15.8 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1021/acsnano.7b06870 Na Li 1 , Qiaoqiao Sun 1 , Zhengze Yu 1 , Xiaonan Gao 1 , Wei Pan 1 , Xiuyan Wan 1 , Bo Tang 1
Affiliation
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Clinical cancer treatments nowadays still face the challenge of recurrence due to the residual cancer cells and minute lesions in surgeries or chemotherapies. To effectively address the problem, we introduce a strategy for constructing cancer cell nuclear-targeted copper sulfide nanoparticles (NPs) with a significant photothermal effect to completely kill residual cancer cells and prevent local cancer recurrence. The NPs could directly target the tumor cells and further enter the nucleus by the surface modification of RGD and TAT peptides. Under the irradiation of 980 nm near-infrared laser, the NPs rapidly increase the temperature of the nucleus, destroy the genetic substances, and ultimately lead to an exhaustive apoptosis of the cancer cells. In vivo experiments show that the designed NPs could effectively treat cancer and prevent the return of cancer with a single laser irradiation for 5 min. The photothermal therapy strategy with nuclear targeting for cancer therapy and anti-recurrence will provide more possibilities to develop efficient platforms for treating cancer.
中文翻译：
核靶向的光热疗法可预防近红外触发的硫化铜纳米颗粒对癌症的复发。
由于外科手术或化学疗法中残留的癌细胞和微小的损伤，如今的临床癌症治疗仍然面临着复发的挑战。为了有效解决该问题，我们引入了一种构建具有显着光热效应的癌细胞核靶向的硫化铜纳米颗粒（NPs）的策略，以完全杀死残留的癌细胞并防止局部癌症复发。NPs可以直接靶向肿瘤细胞，并通过RGD和TAT肽的表面修饰进一步进入细胞核。在980 nm近红外激光的照射下，NP迅速增加了细胞核的温度，破坏了遗传物质，最终导致了癌细胞的彻底凋亡。体内实验表明，所设计的纳米粒子可以有效地治疗癌症并通过单次激光照射5分钟来预防癌症的复发。具有针对癌症治疗和抗复发的核靶向的光热治疗策略将为开发有效的癌症治疗平台提供更多可能性。
更新日期：2018-06-12
中文翻译：
核靶向的光热疗法可预防近红外触发的硫化铜纳米颗粒对癌症的复发。
由于外科手术或化学疗法中残留的癌细胞和微小的损伤，如今的临床癌症治疗仍然面临着复发的挑战。为了有效解决该问题，我们引入了一种构建具有显着光热效应的癌细胞核靶向的硫化铜纳米颗粒（NPs）的策略，以完全杀死残留的癌细胞并防止局部癌症复发。NPs可以直接靶向肿瘤细胞，并通过RGD和TAT肽的表面修饰进一步进入细胞核。在980 nm近红外激光的照射下，NP迅速增加了细胞核的温度，破坏了遗传物质，最终导致了癌细胞的彻底凋亡。体内实验表明，所设计的纳米粒子可以有效地治疗癌症并通过单次激光照射5分钟来预防癌症的复发。具有针对癌症治疗和抗复发的核靶向的光热治疗策略将为开发有效的癌症治疗平台提供更多可能性。
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