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Studies on the Synthesis of Endocyclic Enol Lactones via a RCM of Selected Vinyl Esters
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1021/acs.joc.8b00807 Anna Brodzka 1 , Filip Borys 1 , Dominik Koszelewski 1 , Ryszard Ostaszewski 1
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1021/acs.joc.8b00807 Anna Brodzka 1 , Filip Borys 1 , Dominik Koszelewski 1 , Ryszard Ostaszewski 1
Affiliation
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The novel and efficient approach toward the synthesis of endocyclic enol lactones was devised based on ring-closing metathesis of unsaturated carboxylic acids vinyl esters. Systematic studies revealed that vinyl esters are suitable substrates for RCM reaction. The developed methodology offers an easy route for synthetically challenging target molecules with different functional groups and substitution. We have also demonstrated that vinyl esters of cyclic carboxylic acids can be successfully applied for domino ring-opening ring-closing metathesis sequences.
中文翻译：
通过选定的乙烯基酯的RCM合成内环烯醇内酯的研究
基于不饱和羧酸乙烯基酯的闭环复分解反应，设计了一种新颖，高效的内环烯醇内酯合成方法。系统研究表明，乙烯基酯是适合RCM反应的底物。所开发的方法为合成挑战具有不同官能团和取代基的目标分子提供了一条简便的途径。我们还证明了环状羧酸的乙烯基酯可以成功地用于多米诺环的开环复分解序列。
更新日期：2018-06-12
中文翻译：
通过选定的乙烯基酯的RCM合成内环烯醇内酯的研究
基于不饱和羧酸乙烯基酯的闭环复分解反应，设计了一种新颖，高效的内环烯醇内酯合成方法。系统研究表明，乙烯基酯是适合RCM反应的底物。所开发的方法为合成挑战具有不同官能团和取代基的目标分子提供了一条简便的途径。我们还证明了环状羧酸的乙烯基酯可以成功地用于多米诺环的开环复分解序列。
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