Microbial transformation of thymoquinone (5-isopropyl-2-methyl-cyclohexa-2,5-diene-1,4-dione) (1) by suspended cell-cultures of the plant pathogenic fungus Aspergillus niger resulted in the production of three metabolites. These metabolites were identified as 5-isopropyl-2-methyloxepin-1-one (2), 3-hydroxy-5-isopropyl-2-methylcyclohexa-2,5-diene-1,4-dione (3), and 5-isopropyl-2-methylbenzene-1,4-diol (4) by different spectroscopic methods. Metabolite 2 was found to be a new compound. Compound 4 showed a potent antioxidant activity.

中文翻译：

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使用黑曲霉通过胸腺醌生物转化的新单萜

通过植物病原性真菌黑曲霉的悬浮细胞培养对胸腺醌（5-异丙基-2-甲基-环己-2,5-二烯-1,4-二酮）（1）进行微生物转化，导致产生了三种代谢产物。这些代谢物被鉴定为5-异丙基-2-甲基氧杂庚烯-1-酮（2），3-羟基-5-异丙基-2-甲基环己-2,5-二烯-1,4-二酮（3）和5-异丙基-2-甲基苯-1,4-二醇（4）的光谱方法不同。发现代谢物2是一种新化合物。化合物4显示出有效的抗氧化活性。