Design and preparation of quasi-spherical salt particles as water-soluble porogens to fabricate hydrophobic porous scaffolds for tissue engineering and tissue regeneration†,Materials Chemistry Frontiers

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Design and preparation of quasi-spherical salt particles as water-soluble porogens to fabricate hydrophobic porous scaffolds for tissue engineering and tissue regeneration†
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1039/c8qm00152a
Xiangyu Liang _{1,

2,

3,

4,

5} , Yongli Qi _{1,

2,

3,

4,

5} , Zhen Pan _{1,

2,

3,

4,

5} , Yao He _{1,

2,

3,

4,

5} , Xiangnan Liu _{1,

2,

3,

4,

5} , Shuquan Cui _{1,

2,

3,

4,

5} , Jiandong Ding _{1,

2,

3,

4,

5}

Affiliation

The design and preparation of appropriate porogens are critical in the fabrication of porous scaffolds for tissue engineering and tissue regeneration. Our analysis based on percolation theory reveals that a spherical porogen is better than a cubic porogen. Nevertheless, while porous scaffolds with spherical interior pores have exhibited advantages over those of cubic pores, salt as the most popular and convenient porogen can only be shaped cubically due to the principle of crystallography. Hererin, we propose a strategy to prepare, indirectly, quasi-spherical salt macroparticles simply via gluing small salt particles by sugar melt. The popular biodegradable polymer poly(D,L-lactide-co-glycolide) (PLGA) was employed as the hydrophobic matrix, and polymeric scaffolds with quasi-spherical pores were successfully fabricated by room-temperature compression molding and particulate leaching. Compared to PLGA scaffolds fabricated by conventional cubic salt macroparticles, our improved scaffolds exhibited excellent pore interconnectivity and fewer porogen residues. Two additional advantages of the new fabrication approach were also found: one is quicker porogen leaching by water in the fabrication of PLGA scaffolds, which might be owing to easier water penetration into the intervals of these microparticles; the other is favourable cell adhesion and osteogenic differentiation on the pore wall, which might be attributed to the rough interior surfaces templated from the porogen surfaces composed of many microparticles. The new approach and resultant scaffolds are promising in regenerative medicine.

中文翻译：

设计和制备准球形盐颗粒作为水溶性致孔剂，以制造用于组织工程和组织再生的疏水性多孔支架†

合适的致孔剂的设计和制备对于用于组织工程和组织再生的多孔支架的制造至关重要。我们基于渗流理论的分析表明，球形致孔剂比立方致孔剂更好。然而，尽管具有球形内部孔的多孔支架已经显示出优于立方孔的多孔支架，但是由于晶体学原理，盐作为最流行和最方便的致孔剂只能立方成型。在hererin中，我们提出了一种策略，可以简单地通过糖熔体将小的盐颗粒粘合在一起，从而间接制备准球形盐大颗粒。流行的可生物降解的聚合物聚（d，大号-lactide-共-乙交酯（PLGA）作为疏水性基质，并通过室温压缩成型和颗粒浸出成功地制备了具有准球形孔的聚合物支架。与常规立方盐大颗粒制成的PLGA支架相比，我们改良的支架表现出出色的孔连通性和更少的致孔剂残留。还发现了新的制造方法的两个其他优点：一个是在PLGA支架的制造过程中水引起的致孔剂浸出更快，这可能是由于水更容易渗透到这些微粒的间隔中所致。另一个是在孔壁上有利的细胞粘附和成骨分化，这可能归因于由许多微粒组成的成孔剂表面模板化的粗糙内表面。

更新日期：2018-06-12

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