Although the replacement of ubiquitous palladium catalysts with more sustainable iron-based analogues continues apace, the simple biaryl Suzuki cross-coupling reaction remains stubbornly elusive. It appears that the main issue hampering the reaction is activation of the aryl halide C–X bond. Here we show that a simple N-pyrrole amide and related directing groups on the aryl halide substrates facilitate this process by transient π-coordination to the iron centre. This allows iron-catalysed Suzuki biaryl cross-coupling to proceed, under mild conditions, with alkyllithium-activated aryl pinacol boronic esters.

中文翻译：

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铁催化的底物导向的铃木联芳基交叉偶联

尽管用可持续性更高的铁基类似物替代无处不在的钯催化剂的工作仍在继续，但简单的联芳基铃木交叉偶联反应仍然难以捉摸。似乎阻碍反应的主要问题是芳基卤化物C–X键的活化。在这里，我们显示了一个简单的N-吡咯酰胺和芳基卤化物底物上的相关引导基团通过瞬时π-配位到铁中心促进了这一过程。这允许铁催化的铃木联芳基交叉偶联在温和条件下与烷基锂活化的芳基频哪醇硼酸酯进行。