Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands,Bioorganic & Medicinal Chemistry Letters

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Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2018-06-12 , DOI: 10.1016/j.bmcl.2018.06.019
Ádám Andor Kelemen , Grzegorz Satała , Andrzej J. Bojarski , György M. Keserű

Here we report the design and synthesis of spiro[pyrrolidine-3,3′-oxindole] derivatives representing a novel scaffold of 5-HT₇ receptor ligands. The synthesized analogues were validated as low nanomolar ligands showing selectivity in a panel of related serotonin receptor subtypes including 5-HT_1AR, 5-HT_2AR and 5-HT₆R.

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