Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2018-06-12 , DOI: 10.1016/j.bmcl.2018.06.018 Tomomi Ando , Mina Nagumo , Masayuki Ninomiya , Kaori Tanaka , Robert J. Linhardt , Mamoru Koketsu
Coumarins are ubiquitous in higher plants and exhibit various biological actions. The aim of this study was to investigate the structure-activity relationships of coumarin derivatives on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in human hepatoma HepG2 cells. A series of coumarin derivatives were prepared and assessed for their cytoprotective effects. Among these, a caffeoyl acid-conjugated dihydropyranocoumarin derivative, caffeoyllomatin, efficiently protected against cell damage elicited by t-BHP. Our findings suggest that caffeoyllomatin appears to be a potent cytoprotective agent.
中文翻译:
香豆素衍生物的合成及其对t -BHP诱导的HepG2细胞氧化损伤的细胞保护作用
香豆素普遍存在于高等植物中,并表现出各种生物学作用。这项研究的目的是调查香豆素衍生物对叔丁基过氧化氢(t -BHP)诱导的人肝癌HepG2细胞氧化损伤的构效关系。制备了一系列香豆素衍生物,并对其细胞保护作用进行了评估。其中,与咖啡酸结合的二氢吡喃香豆素衍生物,咖啡酰洛美汀可有效地保护免受t- BHP引起的细胞损伤。我们的研究结果表明,咖啡酰lomatin似乎是一种有效的细胞保护剂。