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Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy†
Lab on a Chip ( IF 6.1 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1039/c8lc00273h
Nanjing Hao 1 , Yuan Nie , Ting Shen , John X J Zhang
Affiliation  

Microfluidics brings unique opportunities for the synthesis of nanomaterials toward efficient liquid biopsy. Herein, we developed the microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluids, providing new insights into the rational design of a particulate system toward the screening and analysis of circulating tumor biomarkers.

中文翻译:

微流控免疫磁性纳米材料的合理设计及其对液体活检的形状影响†

微流控技术为纳米材料的合成和高效液体活检带来了独特的机会。在此,我们通过简单地调节流速,开发了具有可控形状(球体、立方体、棒状和带状)的免疫磁性纳米材料的微反应器流动合成。首次研究了循环肿瘤细胞的颗粒形状依赖性筛选效率,并与商业铁磁流体进行了比较,为颗粒系统的合理设计以筛选和分析循环肿瘤生物标志物提供了新的见解。
更新日期:2018-06-12
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