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Ruthenium‐Catalyzed C–H Bond Heteroarylation of Triazoles Enabled by a Deconvolution Strategy
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2018-08-08 , DOI: 10.1002/ejoc.201800843
Rafael Gramage-Doria 1 , Thierry Roisnel 1
Affiliation  

The application of a deconvolution strategy to ruthenium‐catalyzed C–H bond functionalization provided appropriate reaction conditions to perform the unprecedented heteroarylation of triazole scaffolds in good yields. This was possible after screening 22 parameters (three solvents, three ruthenium complexes as pre‐catalysts, eight carboxylate salts as co‐catalysts and eight bases) in only 18 designed experiments.
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中文翻译:

解卷积策略实现钌催化的三唑CH-H键杂芳基化

将解卷积策略应用于钌催化的C–H键功能化提供了合适的反应条件,以高收率进行了三唑支架空前的杂芳基化反应。仅在18个设计的实验中筛选了22个参数(三种溶剂,三种钌络合物作为前催化剂,八种羧酸盐作为助催化剂和八种碱),就可以做到这一点。
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更新日期:2018-08-08
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