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Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.
Nature Medicine ( IF 58.7 ) Pub Date : 2018-Jul-01 , DOI: 10.1038/s41591-018-0026-6 Donn J Colby 1 , Lydie Trautmann 2, 3 , Suteeraporn Pinyakorn 2, 3 , Louise Leyre 4 , Amélie Pagliuzza 4 , Eugène Kroon 1 , Morgane Rolland 2, 3 , Hiroshi Takata 2, 3 , Supranee Buranapraditkun 2, 3, 5, 6 , Jintana Intasan 1 , Nitiya Chomchey 1 , Roshell Muir 7 , Elias K Haddad 7 , Sodsai Tovanabutra 2, 3 , Sasiwimol Ubolyam 8 , Diane L Bolton 2, 3 , Brandie A Fullmer 9 , Robert J Gorelick 9 , Lawrence Fox 10 , Trevor A Crowell 2, 3 , Rapee Trichavaroj 11 , Robert O'Connell 11 , Nicolas Chomont 4 , Jerome H Kim 2, 12 , Nelson L Michael 2 , Merlin L Robb 2, 3 , Nittaya Phanuphak 1 , Jintanat Ananworanich 1, 2, 3, 13 ,
Nature Medicine ( IF 58.7 ) Pub Date : 2018-Jul-01 , DOI: 10.1038/s41591-018-0026-6 Donn J Colby 1 , Lydie Trautmann 2, 3 , Suteeraporn Pinyakorn 2, 3 , Louise Leyre 4 , Amélie Pagliuzza 4 , Eugène Kroon 1 , Morgane Rolland 2, 3 , Hiroshi Takata 2, 3 , Supranee Buranapraditkun 2, 3, 5, 6 , Jintana Intasan 1 , Nitiya Chomchey 1 , Roshell Muir 7 , Elias K Haddad 7 , Sodsai Tovanabutra 2, 3 , Sasiwimol Ubolyam 8 , Diane L Bolton 2, 3 , Brandie A Fullmer 9 , Robert J Gorelick 9 , Lawrence Fox 10 , Trevor A Crowell 2, 3 , Rapee Trichavaroj 11 , Robert O'Connell 11 , Nicolas Chomont 4 , Jerome H Kim 2, 12 , Nelson L Michael 2 , Merlin L Robb 2, 3 , Nittaya Phanuphak 1 , Jintanat Ananworanich 1, 2, 3, 13 ,
Affiliation
Antiretroviral therapy during the earliest stage of acute HIV infection (Fiebig I) might minimize establishment of a latent HIV reservoir and thereby facilitate viremic control after analytical treatment interruption. We show that 8 participants, who initiated treatment during Fiebig I and were treated for a median of 2.8 years, all experienced rapid viral load rebound following analytical treatment interruption, indicating that additional strategies are required to control or eradicate HIV.
中文翻译：
Fiebig I 急性 HIV 感染者在抗逆转录病毒治疗中断后，HIV RNA 快速反弹。
在急性艾滋病毒感染的最早阶段（Fiebig I）进行抗逆转录病毒治疗可能会最大限度地减少潜在艾滋病毒储存库的建立，从而有利于分析治疗中断后的病毒血症控制。我们发现，在 Fiebig I 期间开始治疗并平均治疗时间为 2.8 年的 8 名参与者在分析治疗中断后均经历了病毒载量快速反弹，这表明需要采取额外的策略来控制或根除 HIV。
更新日期：2018-06-12
中文翻译：
Fiebig I 急性 HIV 感染者在抗逆转录病毒治疗中断后，HIV RNA 快速反弹。
在急性艾滋病毒感染的最早阶段（Fiebig I）进行抗逆转录病毒治疗可能会最大限度地减少潜在艾滋病毒储存库的建立，从而有利于分析治疗中断后的病毒血症控制。我们发现，在 Fiebig I 期间开始治疗并平均治疗时间为 2.8 年的 8 名参与者在分析治疗中断后均经历了病毒载量快速反弹，这表明需要采取额外的策略来控制或根除 HIV。
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