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In Vivo Translation of Peptide-Targeted Drug Delivery Systems Discovered by Phage Display
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-06-11 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00285 Maureen R. Newman 1 , Danielle S. W. Benoit 1
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-06-11 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00285 Maureen R. Newman 1 , Danielle S. W. Benoit 1
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Therapeutic compounds with narrow therapeutic windows and significant systemic side effects benefit from targeted drug delivery strategies. Peptide–protein interactions are often exploited for targeting, with phage display a primary method to identify high-affinity peptide ligands that bind cell surface and matrix bound receptors preferentially expressed in target tissues. After isolating and sequencing high-binding phages, peptides are easily synthesized and chemically modified for incorporation into drug delivery systems, including peptide–drug conjugates, polymers, and nanoparticles. This review describes the phage display methodology to identify targeting peptide sequences, strategies to functionalize drug carriers with phage-derived peptides, specific examples of drug carriers with in vivo translation, and limitations and future applications of phage display to drug delivery.
中文翻译：
噬菌体展示发现的肽靶向药物递送系统的体内翻译
具有治疗窗狭窄和全身性副作用显着的治疗性化合物受益于靶向药物的输送策略。肽-蛋白质相互作用通常被用于靶向，噬菌体展示是鉴定高亲和力肽配体的主要方法，这些配体结合了在靶组织中优先表达的细胞表面和基质结合受体。在对高结合性噬菌体进行分离和测序后，可以轻松合成肽并对其进行化学修饰，以将其掺入药物输送系统中，包括肽-药物结合物，聚合物和纳米颗粒。这篇评论文章描述了噬菌体展示方法，以鉴定靶向肽序列，用噬菌体衍生的肽功能化药物载体的策略，具有体内翻译的药物载体的具体实例，
更新日期：2018-06-11
中文翻译：
噬菌体展示发现的肽靶向药物递送系统的体内翻译
具有治疗窗狭窄和全身性副作用显着的治疗性化合物受益于靶向药物的输送策略。肽-蛋白质相互作用通常被用于靶向，噬菌体展示是鉴定高亲和力肽配体的主要方法，这些配体结合了在靶组织中优先表达的细胞表面和基质结合受体。在对高结合性噬菌体进行分离和测序后，可以轻松合成肽并对其进行化学修饰，以将其掺入药物输送系统中，包括肽-药物结合物，聚合物和纳米颗粒。这篇评论文章描述了噬菌体展示方法，以鉴定靶向肽序列，用噬菌体衍生的肽功能化药物载体的策略，具有体内翻译的药物载体的具体实例，
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