Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy†,Journal of Materials Chemistry B

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Octahedral molybdenum clusters as radiosensitizers for X-ray induced photodynamic therapy†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-11 00:00:00 , DOI: 10.1039/c8tb00893k
Kaplan Kirakci _{1,

2} , Jaroslav Zelenka _{2,

3,

4,

5} , Michaela Rumlová _{2,

4,

5,

6} , Jiří Martinčík _{2,

7,

8,

9,

10} , Martin Nikl _{2,

10,

11,

12} , Tomáš Ruml _{2,

3,

4,

5} , Kamil Lang _{1,

2}

Affiliation

The use of radiosensitizers recently emerged as a promising approach to circumvent the depth penetration limitations of photodynamic therapy of cancer and to enhance radiotherapeutical effects. A widely explored current strategy is based on complex nanoarchitectures that facilitate the transfer of energy harvested from X-ray radiation by scintillating nanoparticles to the surrounding photosensitizer molecules to generate reactive oxygen species, mostly singlet oxygen O₂(¹Δ_g). We describe an alternative approach aiming at a considerable simplification of the architecture. The presented nanoparticles, made of the luminescent octahedral molybdenum cluster compound (n-Bu₄N)₂[Mo₆I₈(OCOCF₃)₆], efficiently absorb X-rays due to the high content of heavy elements, leading to the formation of the excited triplet states that interact with molecular oxygen to produce O₂(¹Δ_g). The activity of the nanoparticles on HeLa cells was first investigated under UVA/blue-light irradiation in order to prove the biological effects of photosensitized O₂(¹Δ_g); there is no dark toxicity at micromolar concentrations, but strong phototoxicity in the nanomolar range. The nanoparticles significantly enhance the antiproliferative effect of X-ray radiation in vitro at lower concentration than for previously reported O₂(¹Δ_g) radiosensitizing systems and this effect is more pronounced on cancer HeLa cells than non-cancer MRC cells. The results demonstrate that the cluster-based radiosensitizers of O₂(¹Δ_g) have strong potential with respect to the enhancement of the efficacy of radiotherapy with exciting opportunities for cancer treatment.

中文翻译：

八面体钼簇作为放射增敏剂，用于X射线诱导的光动力疗法†

近年来，放射增敏剂的使用已成为一种有前途的方法，可用来规避癌症光动力疗法的深度渗透限制并增强放射治疗效果。一种广泛探索当前策略是基于复杂nanoarchitectures促进从X射线辐射收集的能量的由闪烁纳米颗粒传递到周围光敏剂分子以产生反应性氧物质，主要是单线态氧Ô ₂（¹ Δ_克）。我们描述了一种旨在显着简化体系结构的替代方法。提出的纳米颗粒，由发光的八面体钼簇化合物（n -Bu ₄ N）₂ [Mo₆我₈（OCOCF₃）₆ ]，有效地吸收X射线，由于重元素的含量高，导致激发三重态的形成与分子氧，以产生ö相互作用₂（¹ Δ_克）。对HeLa细胞中的纳米颗粒的活性是第一UVA /蓝色光照射下研究为了证明的生物效应光敏Ô₂（¹ Δ_克）; 在微摩尔浓度下没有暗毒性，但在纳摩尔范围内有很强的光毒性。纳米粒子显着增强了体外X射线辐射的抗增殖作用在比以前报道的较低浓度Ô ₂（¹ Δ_克）放射增敏系统，该效果更显着对癌细胞HeLa细胞比非癌症MRC细胞。结果表明，0的基于集群的放射增敏剂₂（¹ Δ_克）已经强大的潜力相对于放射治疗与用于癌症治疗的令人兴奋的机会的效果的增强。

更新日期：2018-06-11

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