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Light- and pH-dually responsive dendrimer-star copolymer containing spiropyran groups: synthesis, self-assembly and controlled drug release†
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-06-11 00:00:00 , DOI: 10.1039/c8py00721g
Weizhong Yuan 1, 2, 3, 4, 5 , Xueyuan Gao 1, 2, 3, 4, 5 , Erli Pei 1, 2, 3, 4, 5 , Zhihong Li 6, 7, 8, 9
Affiliation  

Amphiphilic dendrimer-star copolymer poly(ε-caprolactone)-block-poly(methacrylic acid-co-spiropyran methacrylate) (DPCL-b-P(MAA-co-SPMA)) was synthesized by the combination of ring-opening polymerization (ROP), atom transfer radical polymerization (ATRP), acidolysis and DCC reactions. The copolymer could self-assemble into spherical micelles in water. In the copolymer, spiropyran (SP) groups displayed light- and pH-dually responsive properties through UV light irradiation and altering the pH values of micelle solutions. Upon UV light irradiation or at low pH, the hydrophobic spiropyran (SP) isomerized to the hydrophilic merocyanine (MC) or merocyanine H+ (MCH). Besides, the PMAA segments also presented pH-responsive properties. Therefore, the morphologies of the micelles could be adjusted by UV/Vis light irradiation or by altering the pH values. The copolymer micelles were used as the drug delivery system for the controlled release of the anticancer drug doxorubicin (DOX). The cytotoxicity investigation showed that the copolymer micelles possessed good biocompatibility. As a result, the dendrimer-star copolymer is expected to be used as an intelligent carrier of hydrophobic drugs.

中文翻译:

含有螺吡喃基团的对光和pH值都具有响应的树状聚合物-星形共聚物:合成,自组装和受控药物释放

两亲性树枝状大分子星形共聚物聚(ε -己内酯) -嵌段-聚(甲基丙烯酸--spiropyran丙烯酸甲酯)(DPCL- b -P(MAA--SPMA))通过开环聚合的组合(ROP合成),原子转移自由基聚合(ATRP),酸解和DCC反应。该共聚物可以在水中自组装成球形胶束。在共聚物中,螺吡喃(SP)基团通过紫外线照射并改变胶束溶液的pH值,表现出对光和pH的响应特性。在紫外线照射下或在低pH下,疏水性螺吡喃(SP)异构化为亲水性花菁(MC)或花菁H +(MCH)。此外,PMAA链段还具有pH响应特性。因此,可以通过UV / Vis光照射或通过改变pH值来调节胶束的形态。共聚物胶束被用作药物递送系统,以控制释放抗癌药物阿霉素(DOX)。细胞毒性研究表明,该共聚物胶束具有良好的生物相容性。结果,预期树枝状聚合物-星形共聚物将用作疏水性药物的智能载体。
更新日期:2018-06-11
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