A polyketide synthase and nonribosomal peptide synthetase hybrid gene cluster from the genome of Penicillium thymicola was identified through genome mining. Heterologous expression of this cluster leads to the production of pyranonigrin A. A series of experiments established that only four genes are sufficient to biosynthesize pyranonigrin A. Based on the results from the current study, a biosynthetic pathway of pyranonigrin A is proposed. © 2018 American Institute of Chemical Engineers AIChE J, 64: 4182–4186, 2018

中文翻译：

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胸腺青霉IBT 5891中通过基因组挖掘鉴定吡喃酮A生物合成基因簇

通过基因组挖掘鉴定了来自胸腺青霉基因组的聚酮化合物合酶和非核糖体肽合成酶杂合基因簇。该簇的异源表达导致吡喃酮A的产生。一系列实验确定只有四个基因足以生物合成吡喃酮A。基于当前研究的结果，提出了吡喃酮A的生物合成途径。©2018美国化学工程师学会AIChE J，64：4182–4186，2018