BSA‐IrO2: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics,Angewandte Chemie International Edition

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BSA‐IrO2: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-07-12 , DOI: 10.1002/anie.201804466
Wenyao Zhen _{1,

2} , Yang Liu _{1,

2} , Lin Lin ₃ , Jing Bai ₁ , Xiaodan Jia ₁ , Huayu Tian _{2,

3} , Xiue Jiang _{1,

2}

Affiliation

Intrinsically integrating precise diagnosis, effective therapy, and self‐anti‐inflammatory action into a single nanoparticle is attractive for tumor treatment and future clinical application, but still remains a great challenge. In this study, bovine serum albumin–iridium oxide nanoparticles (BSA‐IrO₂ NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, and a high X‐ray absorption coefficient were prepared through one‐step biomineralization. The nanoparticles allow tumor phototherapy and simultaneous photoacoustic/thermal imaging and computed tomography. More importantly, BSA‐IrO₂ NPs can also act as a catalase to protect normal cells against H₂O₂‐induced reactive oxygen pressure and inflammation while significantly enhancing photoacoustic imaging through microbubble‐based inertial cavitation. These remarkable features may open up the exploration iridium‐based nanomaterials in theranostics.

中文翻译：

BSA-IrO2：具有类似光催化酶的纳米粒子，具有高的光热转换效率和较高的X射线吸收系数，可用于抗发炎和抗肿瘤治疗

将精确的诊断，有效的治疗和抗炎的作用本质上整合到单个纳米颗粒中对于肿瘤治疗和未来的临床应用很有吸引力，但仍然是一个巨大的挑战。在这项研究中，通过一步生物矿化制备了具有卓越的光热转化效率，良好的光催化活性和高X射线吸收系数的牛血清白蛋白-氧化铱纳米颗粒（BSA-IrO ₂ NPs）。纳米粒子可以进行肿瘤光疗，同时进行光声/热成像和计算机断层扫描。更重要的是，BSA-IrO ₂ NP也可以作为过氧化氢酶来保护正常细胞免受H ₂ O _2的侵害。通过基于微气泡的惯性空化来显着增强光声成像，从而诱发活性氧压和炎症。这些非凡的功能可能会打开基于铱的纳米材料的研究。

更新日期：2018-07-12

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