The first [3+3] cyclization of 2‐indolylmethanols with vinylcyclopropanes has been established under iridium catalysis. The reaction regioselectively constructs tetrahydrocarbazole frameworks bearing two vicinal all‐carbon quaternary stereocenters in high yields (up to 99%, up to 20:1 rr). This reaction not only is the first example of a metal‐catalyzed [3+3] cyclization of 2‐indolylmethanols but also is the first one‐step [3+3] cyclization of vinylcyclopropanes. More importantly, this reaction shows reversed regioselectivity compared to other 2‐indolylmethanol‐involved transformations, which will advance the chemistry of 2‐indolylmethanols.

中文翻译：

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通过金属催化与乙烯基环丙烷的2-吲哚甲醇的区域选择性[3 + 3]环化

在铱催化下，已经建立了2-吲哚基甲醇与乙烯基环丙烷的第一个[3 + 3]环化反应。该反应区域选择性地以高产率（高达99％，高达20：1 rr）构建带有两个邻近的全碳四元立体中心的四氢咔唑骨架。该反应不仅是2-吲哚基甲醇在金属催化下[3 + 3]环化的第一个例子，而且还是乙烯基环丙烷的第一步[3 + 3]环化的例子。更重要的是，与其他2吲哚基甲醇参与的转化相比，该反应显示出反向的区域选择性，这将促进2吲哚基甲醇的化学反应。