Ruthenium‐Pincer‐Catalyzed Hydrogenation of Lactams to Amino Alcohols,Chemistry - An Asian Journal

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Ruthenium‐Pincer‐Catalyzed Hydrogenation of Lactams to Amino Alcohols
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-07-23 , DOI: 10.1002/asia.201800759
Jiangbo Chen ₁ , Jiaquan Wang ₁ , Tao Tu _{1,

2}

Affiliation

By using the commercially available ruthenium pincer complex (Ru‐MACHO‐BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value‐added amino alcohols in good‐to‐excellent yields under mild reaction conditions. Remarkably, in addition to N‐protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

中文翻译：

内酰胺的钌针催化氢化为氨基醇

通过使用市售的钌夹钳络合物（Ru‐MACHO‐BH）作为催化剂，成功完成了具有挑战性的内酰胺和类似物的直接氢化反应，以在温和的反应条件下以良好或优异的产率提供相应的增值氨基醇。值得注意的是，除了N保护的内酰胺外，在催化量的弱碱存在下甚至在中性反应条件下，未保护的内酰胺也可以轻松还原，这进一步突出了广泛的底物范围和操作效率。

更新日期：2018-07-23

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