The aim of the study was to investigate pharmacotherapeutic potential of Naringenin and its brain targeted nanoformulations in Autism Spectrum Disorders (ASD).

ASD like phenotype was induced by infusion of 1 M Propanoic acid into anterior portion of lateral ventricle in rats. Naringenin (25, 50 and 100 mg/kg), uncoated and coated (glutathione & tween 80) naringenin loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (25 mg/kg) and minocycline (50 mg/kg) were administered orally for 29 days. Neurobehavioural, biochemical, blood-brain barrier permeability, TNF-α, MMP-9, HSP-70 and P-glycoprotein tests were performed.

Naringenin and its nanoparticles significantly restored behavioural and biochemical deficits in ASD phenotype. Glutathione and tween 80 coated nanoparticles enhanced brain delivery of NGN by inhibition of P-glycoprotein. Naringenin (100 mg/kg) and its nanocarriers (25 mg/kg) demonstrated pharmacological efficacy comparable to minocycline (50 mg/kg).

Naringenin and its coated nanocarriers have strong clinical potential as an adjunct neurotherapeutic moiety in attenuating neuropsychopathology associated with ASD.

该研究的目的是研究柚皮素及其在自闭症谱系障碍（ASD）中的脑靶向纳米制剂的药物治疗潜力。

通过向大鼠侧脑室前部注入1 M丙酸来诱导ASD样表型。柚皮素（25、50和100 mg / kg），未包衣和包衣（谷胱甘肽和吐温80），装有柚木素的聚乳酸-乙醇酸（PLGA）纳米颗粒（25 mg / kg）和米诺环素（50 mg / kg）口服29天。进行了神经行为学，生化，血脑屏障通透性，TNF-α，MMP-9，HSP-70和P-糖蛋白测试。

柚皮素及其纳米颗粒可显着恢复ASD表型的行为和生化缺陷。谷胱甘肽和吐温80包被的纳米颗粒通过抑制P-糖蛋白增强了NGN的脑传递。柚皮素（100 mg / kg）及其纳米载体（25 mg / kg）具有与米诺环素（50 mg / kg）相当的药理功效。

柚皮素及其包被的纳米载体在减弱与ASD相关的神经精神病理学方面作为辅助神经治疗部分具有强大的临床潜力。