Olaquindox, is a growth-promoting feed additive for food-producing animals. As the banned medicinal feed additive, olaquindox in animal feed and water must be concerned as an important hazard index. To improve studies of the toxicity of olaquindox, we provide a toxicological effects of olaquindox on a common freshwater fish, Cyprinus carpio L. The results of acute toxicity tests showed that the 7d-LD₅₀ of olaquindox administered by feeding for common carp was determined to be 3746.3 mg/kg. We also found that the accumulation coefficient of olaquindox in carp was 1.45–1.9. Based on the studied hematological and blood biochemical parameters (RBCs count, hemoglobin content, ALT, AST and SOD activity), we found that olaquindox induced significant alterations in all studied parameters. Regarding bioaccumulation, the results showed that olaquindox had more efficiency to internalize fish tissues (liver, kidneys and muscle). The histopathological investigation of tissues from poisoning fish revealed various alterations that varied between adaptation responses and permanent tissue damage. Our results indicate that olaquindox are toxic to common carp and have obvious accumulation, and all the data from acute and subacute toxicity experiments in common carp may provide a useful tool for assessing the toxicity of olaquindox to aquatic organisms.

Olaquindox是用于食品生产动物的促进生长的饲料添加剂。作为被禁止的药用饲料添加剂，动物饲料和水中的喹喔啉必须作为重要的危害指标来考虑。为了改善对喹乙醇的毒性的研究，我们提供了喹喹对普通淡水鱼鲤鱼的毒理作用。急性毒性试验的结果表明，7d-LD ₅₀测定通过喂食鲤鱼的奥拉喹多的最大摄入量为3746.3 mg / kg。我们还发现，鲤鱼中喹啉的积累系数为1.45–1.9。根据研究的血液学和血液生化参数（RBC计数，血红蛋白含量，ALT，AST和SOD活性），我们发现olaquindox引起所有研究参数的显着改变。关于生物蓄积性，结果表明，喹乙醇具有更强的内在化鱼类组织（肝脏，肾脏和肌肉）的效率。对中毒鱼类组织的组织病理学调查显示，适应反应和永久性组织损伤之间存在各种变化。我们的结果表明，喹乙醇对鲤鱼有毒性，并具有明显的蓄积性，