Metabolic homeostasis is critical to cellular and organismal health. The newly revealed crystal structures of the endocrine factors FGF21 and FGF23, in association with the glycosidase coreceptor Klotho and transmembrane tyrosine kinase FGFR, set a platform for structure-based novel drug design against common metabolic disorders.

中文翻译：

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揭示内分泌FGF信号复合物与代谢性疾病的斗争

代谢稳态对细胞和机体健康至关重要。内分泌因子FGF21和FGF23的新揭示的晶体结构，与糖苷酶共受体Klotho和跨膜酪氨酸激酶FGFR结合，为针对常见代谢性疾病的基于结构的新药设计奠定了平台。