当前位置: X-MOL 学术Nano Res. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
High-density lipoprotein mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases
Nano Research ( IF 9.5 ) Pub Date : 2018-06-08 , DOI: 10.1007/s12274-018-2101-1
Song Ih Ahn , Hyun-Ji Park , Jiwon Yom , Taeyoung Kim , YongTae Kim

High-density lipoprotein (HDL) serves as a natural nanoparticle with compositional and functional heterogeneity and contributes to the maintenance of lipid metabolism and various biological functions. HDL also transports endogenous microRNAs, vitamins, hormones, and proteins through blood and interstitial fluids to various organs. These unique and diverse features of HDL have encouraged its applications for the transport of therapeutics and diagnostic reagents in the last decade. In this review, we describe the heterogeneous characteristics and biological functions of HDL and highlight HDL mimetic approaches, including apolipoprotein mimetic peptides and reconstituted HDL nanoparticles. Given the potential of HDL as a nanocarrier delivering various therapeutic agents, we discuss the current representative studies of HDL mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases and analyze the current challenges and future perspective.



中文翻译:

用于心血管和神经退行性疾病的高密度脂蛋白模拟纳米疗法

高密度脂蛋白(HDL)是具有组成和功能异质性的天然纳米颗粒,有助于维持脂质代谢和各种生物学功能。HDL还通过血液和组织液将内源性microRNA,维生素,激素和蛋白质转运到各个器官。在过去的十年中,HDL的这些独特而多样的功能鼓励了其在治疗剂和诊断试剂的运输中的应用。在这篇综述中,我们描述了HDL的异质性和生物学功能,并重点介绍了HDL模拟方法,包括载脂蛋白模拟肽和重组HDL纳米颗粒。鉴于HDL作为提供各种治疗剂的纳米载体的潜力,

更新日期:2018-06-08
down
wechat
bug