Tumor targeting dual stimuli responsive controllable release nanoplatform based on DNA-conjugated reduced graphene oxide for chemo-photothermal synergetic cancer therapy†,Journal of Materials Chemistry B

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Tumor targeting dual stimuli responsive controllable release nanoplatform based on DNA-conjugated reduced graphene oxide for chemo-photothermal synergetic cancer therapy†
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2018-06-08 00:00:00 , DOI: 10.1039/c8tb00670a
Wenjing Jiang _{1,

2,

3,

4,

5} , Fan Mo _{1,

2,

3,

4,

5} , Yaohui Lin _{1,

2,

3,

4,

5} , Xusheng Wang _{1,

2,

3,

4,

5} , LiangJun Xu _{1,

2,

3,

4,

5} , FengFu Fu _{1,

2,

3,

4,

5}

Affiliation

In this research, a novel tumor targeting dual stimuli responsive nanoplatform was fabricated for the controllable delivery and release of a drug to realize chemo-photothermal synergetic cancer therapy by integrating a DNA aptamer with polydopamine reduced graphene oxide (rGO-PDA) nanosheets. The rGO-PDA nanosheets simultaneously acted as a near-infrared radiation (NIR) photothermal agent to generate hyperthermia for photothermal therapy and a nano-carrier for loading doxorubicin (DOX), and the specially designed DNA aptamer served as a supplementary carrier for DOX loading as well as targeting moiety/gatekeeper for specific cellular recognition and controllable release of DOX. The proposed nanoplatform possessed a good targeting ability, remarkable photothermal conversion ability and intelligent drug release with both pH and photothermal heating dual stimuli response. The nanoplatform was successfully used to selectively deliver DOX to protein tyrosine kinase 7 over-expressing cancer cells with a loading capacity of 1.56 mg mg⁻¹ and controllable drug release, which responded to both acidic intracellular environments and NIR irradiation. The combination of the dual stimuli responsive controllable release and the dual nanocarrier for drug loading results in efficient chemo-photothermal synergetic therapy and holds great potential for multimodal cancer therapy.

中文翻译：

基于DNA偶联的还原氧化石墨烯的靶向靶向双刺激响应的可控释放纳米平台的化学-光热协同癌症治疗†

在这项研究中，针对双刺激响应纳米平台的新型肿瘤被制造出来，用于通过将DNA适体与聚多巴胺还原氧化石墨烯（rGO-PDA）纳米片相结合，实现药物的可控递送和释放，从而实现化学-光热协同癌症治疗。rGO-PDA纳米片同时充当近红外辐射（NIR）光热剂以产生用于光热疗法的热疗和用于装载阿霉素（DOX）的纳米载体，并且专门设计的DNA适体充当了用于DOX装载的辅助载体以及靶向部分/关守，以实现特定的细胞识别和DOX的可控释放。拟议的纳米平台具有良好的靶向能力，出色的光热转化能力和智能的药物释放，同时具有pH和光热加热双重刺激响应。纳米平台已成功用于选择性地将DOX递送至蛋白酪氨酸激酶7过表达的癌细胞，其负载能力为1.56 mg mg^-1和可控的药物释放，对酸性细胞内环境和NIR辐射都有反应。双重刺激响应的可控释放和双重纳米载体用于载药的组合导致有效的化学-光热协同治疗，并在多模式癌症治疗中具有巨大潜力。

更新日期：2018-06-08

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