Cyclodextrin-based host–guest supramolecular hydrogel and its application in biomedical fields,Polymer Chemistry

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Cyclodextrin-based host–guest supramolecular hydrogel and its application in biomedical fields
Polymer Chemistry ( IF 4.1 ) Pub Date : 2018-06-08 00:00:00 , DOI: 10.1039/c8py00730f
Guiting Liu _{1,

2,

3,

4} , Qijuan Yuan _{1,

2,

3,

4} , Geoffrey Hollett _{5,

6,

7,

8} , Wei Zhao _{2,

9,

10,

11,

12} , Yang Kang _{12,

13,

14,

15,

16} , Jun Wu _{1,

2,

3,

4}

Affiliation

School of Biomedical Engineering
Sun Yat-sen University
Guangzhou
P. R. China
Materials Science and Engineering Program
University of California San Diego
La Jolla
USA
Laboratory for Stem Cells and Tissue Engineering
Ministry of Education
Guangzhou 510080
China
Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization
Chengdu Institute of Biology
Chinese Academy of Sciences
Chengdu

The cyclodextrin (CD) based host–guest inclusion complexation between cyclodextrins (CDs) and guest moieties has inspired the fabrication of novel supramolecular hydrogels for biomedical applications. From a topology of view, this article reviews the recent developments of two kinds of CD-based supramolecular hydrogels and their applications in biomedical fields respectively. On one hand, supramolecular hydrogels derived from CD-based poly(pseudo)rotaxanes generally displayed thixotropic and reversible properties and have been extensively developed as injectable drug delivery systems. On the other hand, supramolecular hydrogels based on the host–guest interaction between CDs and small guest moieties generally exhibited stimuli-responsive behaviors, typically the release of therapeutic agents. The development of CD-based supramolecular hydrogels provides a new platform for the design of novel biomaterials.

中文翻译：

基于环糊精的宿主-客体超分子水凝胶及其在生物医学领域中的应用

环糊精（CD）和客体部分之间基于环糊精（CD）的宿主-客体包合络合物激发了新型生物医学应用的超分子水凝胶的制备。本文从拓扑学的角度回顾了两种基于CD的超分子水凝胶的最新进展及其分别在生物医学领域中的应用。一方面，衍生自基于CD的聚（假）轮烷的超分子水凝胶通常具有触变性和可逆性，并已被广泛开发为可注射药物递送系统。另一方面，基于CD和小客体部分之间的客体相互作用的超分子水凝胶通常表现出刺激反应行为，通常是治疗剂的释放。

更新日期：2018-06-08

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