Pd(ii)-Catalyzed gamma-C(sp3)–H alkynylation of amides: selective functionalization of R chains of amides R1C(O)NHR†,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Pd(ii)-Catalyzed gamma-C(sp3)–H alkynylation of amides: selective functionalization of R chains of amides R1C(O)NHR†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-08 00:00:00 , DOI: 10.1039/c8cc03445a
Vinod G. Landge _{1,

2,

3,

4} , Ayisha Parveen _{1,

2,

3,

4} , Avanashiappan Nandakumar _{1,

2,

3,

4} , Ekambaram Balaraman _{1,

2,

3,

4}

Affiliation

The gamma C(sp³)–H bond alkynylation of R chains of amides R¹C(O)NHR, a fundamental class of synthetic substrates, has not been accomplished to date. Here, the first example of palladium(II)-catalyzed alkynylation of an unactivated gamma C(sp³)–H bond of alkyl amides (cyclic, linear, and amino acids) is reported. The kinetic experiment shows that the rate of the reaction depends on the coupling partners and the amides. Late-stage diversification of alkynylated amides was developed by utilizing amine and alkyne functionalities.

中文翻译：

Pd（ii）催化的酰胺的γ-C（sp ³）-H烷基化：酰胺R链的选择性官能化R ¹ C（O）NHR †

到目前为止，尚未完成酰胺R ¹ C（O）NHR的R链的C链C（sp ³）-H键的炔基化反应。在此，报道了钯（II）催化烷基酰胺（环状，线性和氨基酸）的未活化γC（sp ³）-H键的炔基化反应的第一个例子。动力学实验表明，反应速率取决于偶联伙伴和酰胺。通过利用胺和炔烃官能团开发了烷基化酰胺的后期多样化产品。

更新日期：2018-06-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11