Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection†,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-08 00:00:00 , DOI: 10.1039/c8cc03865a
Shuhei Kosono ₁ , Akihiro Kasai ₁ , Sumika Komaba ₁ , Teruhiko Matsubara ₂ , Toshinori Sato ₂ , Daisuke Takahashi ₁ , Kazunobu Toshima ₁

Affiliation

Among a series of chemically synthesized fucoidan derivatives (1–9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C₃-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

中文翻译：

新型血凝素结合硫酸化低聚岩藻糖苷及其对流感病毒感染的影响†

在一系列化学合成的岩藻依聚糖衍生物( 1-9 )中，首次发现5能与流感病毒血凝素(HAs)结合并抑制血凝活性。此外，用5的三个硫酸化低聚岩藻糖苷部分合成的设计的C ₃对称三足配体10表现出比5更高的血凝抑制活性。使用 MDCK 细胞进行的噬菌斑测定表明10可以有效抑制流感病毒感染。

更新日期：2018-06-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11