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Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-06-08 00:00:00 , DOI: 10.1039/c8cc03865a
Shuhei Kosono 1 , Akihiro Kasai 1 , Sumika Komaba 1 , Teruhiko Matsubara 2 , Toshinori Sato 2 , Daisuke Takahashi 1 , Kazunobu Toshima 1
Affiliation  

Among a series of chemically synthesized fucoidan derivatives (1–9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.

中文翻译:


新型血凝素结合硫酸化低聚岩藻糖苷及其对流感病毒感染的影响†



在一系列化学合成的岩藻依聚糖衍生物( 1-9 )中,首次发现5能与流感病毒血凝素(HAs)结合并抑制血凝活性。此外,用5的三个硫酸化低聚岩藻糖苷部分合成的设计的C 3对称三足配体10表现出比5更高的血凝抑制活性。使用 MDCK 细胞进行的噬菌斑测定表明10可以有效抑制流感病毒感染。
更新日期:2018-06-08
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