Chloroquine has been recommended for Plasmodium vivax infections for >60 years, but resistance is increasing. To guide future therapies, the cumulative benefits of using slowly eliminated (chloroquine) vs rapidly eliminated (artesunate) antimalarials, and the risks and benefits of adding radical cure (primaquine) were assessed in a 3-way randomized comparison conducted on the Thailand-Myanmar border.

中文翻译：

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氯喹、青蒿琥酯和氯喹-伯氨喹治疗间日疟原虫疟疾的累积疗效和安全性比较


氯喹被推荐用于治疗间日疟原虫感染已超过 60 年，但耐药性正在增加。为了指导未来的治疗，在泰国和缅甸进行的三向随机比较中评估了使用缓慢消除（氯喹）与快速消除（青蒿琥酯）抗疟药的累积益处，以及添加根治性治疗（伯氨喹）的风险和益处边界。