Rh‐Catalyzed Carboxylates Directed C–H Activation for the Synthesis of ortho‐Carboxylic 2‐Arylethenesulfonyl Fluorides: Access to Unique Electrophiles for SuFEx Click Chemistry,European Journal of Organic Chemistry

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Rh‐Catalyzed Carboxylates Directed C–H Activation for the Synthesis of ortho‐Carboxylic 2‐Arylethenesulfonyl Fluorides: Access to Unique Electrophiles for SuFEx Click Chemistry
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-13 , DOI: 10.1002/ejoc.201800762
Shi-Meng Wang ₁ , Balakrishna Moku ₁ , Jing Leng ₁ , Hua-Li Qin ₁

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A carboxylic ester directed monoselective coupling of sp² C–H bonds with ethenesulfonyl fluoride (ESF) was achieved by using a Rh^III catalyst. This protocol gives access to a class of ortho‐carboxylic‐functionalized 2‐arylethenesulfonyl fluorides. The versatile and unique properties of carboxylic groups will significantly improve the capability of using 2‐arylethenesulfonyl fluorides as covalent probes and in drug discovery.

中文翻译：

Rh催化的羧酸盐指示C–H活化，用于合成邻羧酸2-芳烷基磺酰氟：SuFEx Click化学方法获得独特的亲电试剂

通过使用Rh ^III催化剂，可以实现羧酸酯定向的sp ² C–H键与乙磺酰氟（ESF）的单选择性偶联。通过该协议，可以访问一类邻羧基功能化的2-芳烷基磺酰氟。羧基的通用性和独特性将显着提高使用2-芳烷基磺酰氟作为共价探针和进行药物发现的能力。

更新日期：2018-08-13

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