Synthesis of a Fluorescent Probe for Sensing Multiple Protein States,European Journal of Organic Chemistry

当前位置： X-MOL 学术 › Eur. J. Org. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Synthesis of a Fluorescent Probe for Sensing Multiple Protein States
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-08-13 , DOI: 10.1002/ejoc.201800524
Oleksandr A. Kucherak ₁ , Volodymyr V. Shvadchak ₁ , Yevhenii A. Kyriukha ₁ , Dmytro A. Yushchenko ₁

Affiliation

A thiol‐reactive solvatochromic probe with two‐band emission was synthesized. It was applied for labelling amyloidogenic protein α‐synuclein, and was shown to discriminate at least three protein forms: unstructured, membrane‐bound and amyloid form. The presented approach may be used in the development of fluorescent sensors for protein interactions and transformations.