Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice,Food & Function

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Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice
Food & Function ( IF 5.1 ) Pub Date : 2018-06-08 00:00:00 , DOI: 10.1039/c8fo00081f
Fangfang Dang _{1,

2,

3,

4,

5} , Yujun Jiang _{1,

2,

3,

4,

5} , Ruili Pan _{1,

2,

3,

4,

5} , Yanhong Zhou _{1,

2,

3,

4,

5} , Shuang Wu _{1,

2,

3,

4,

5} , Rui Wang _{1,

2,

3,

4,

5} , Kejin Zhuang _{1,

2,

3,

4,

5} , Wei Zhang _{1,

2,

3,

4,

5} , Tiejing Li _{1,

2,

3,

4,

5} , Chaoxin Man _{1,

2,

3,

4,

5}

Affiliation

Probiotics have been proposed as an option for the prevention of type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate the hypoglycemic effects of Lactobacillus paracasei on diabetic mice and explore the possible underlying molecular mechanism. The α-glucosidase inhibitory activities of eight L. paracasei strains were assessed in vitro. L. paracasei TD062 with high α-glucosidase inhibitory activity (31.9%) showed an excellent antidiabetic ability and it could survive in simulated gastrointestinal juices. To investigate the beneficial effects of L. paracasei TD062, diabetic mice were treated with the strain at 10⁹, 10⁸ and 10⁷ CFU ml⁻¹. The results indicated that the administration of L. paracasei TD062 could regulate the levels of fasting blood glucose (FBG), postprandial blood glucose (PBG), glucose tolerance, hepatic glycogen and lipid metabolism. In addition, the antioxidant capacity was also improved by oral administration of L. paracasei TD062. And the hypoglycemic effects exhibited dose dependence to some extent. Furthermore, it was revealed that L. paracasei TD062 had a positive effect on the expression levels of genes related to glucose metabolism and the PI3K/Akt pathway. These results demonstrated that L. paracasei TD062 played an important role in preventing the development of T2DM and might be applied as a new type of hypoglycemic agent in functional foods.

中文翻译：

副干酪乳杆菌的 施用改善了小鼠的2型糖尿病

益生菌已被提议作为预防2型糖尿病（T2DM）的一种选择。这项研究的目的是评估副干酪乳杆菌对糖尿病小鼠的降血糖作用，并探讨可能的潜在分子机制。在体外评估了八种副干酪乳杆菌的α-葡萄糖苷酶抑制活性。具有高α-葡糖苷酶抑制活性（31.9％）的副干酪乳杆菌TD062显示出优异的抗糖尿病能力，并且可以在模拟胃肠液中存活。为了研究的有益效果副干酪乳杆菌TD062，糖尿病小鼠用应变以10处理过的⁹，10 ⁸和10⁷ CFU ml^-1。结果表明，副干酪乳杆菌TD062的施用可以调节空腹血糖（FBG），餐后血糖（PBG），葡萄糖耐量，肝糖原和脂质代谢水平。另外，通过口服副干酪乳杆菌TD062也提高了抗氧化能力。降血糖作用在一定程度上表现出剂量依赖性。此外，揭示了副干酪乳杆菌TD062对与葡萄糖代谢和PI3K / Akt途径有关的基因的表达水平具有积极作用。这些结果表明副干酪乳杆菌 TD062在预防T2DM的发展中起着重要作用，可能作为功能性食品中的新型降血糖剂应用。

更新日期：2018-06-08

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